Endocrine Abstracts

Introduction: The majority of adrenocortical incidentalomas (AIs) are nonfunctional adenomas. Some of them demonstrate an autonomous cortisol secretion (ACS), a pathologic condition defined as biochemical evidence of hypercortisolism without typical signs or symptoms of Cushing’s syndrome.Subjects and methods: In this cross-sectional study, we evaluated 152 consecutive patients, aged 58.3 years (range, 25-84 years) of whom 105 (69.1%) with unilatera...

Introduction: Multiple endocrine neoplasia type 2 is an autosomal dominant polyglandular cancer syndrome. It arises as a result of a germline mutation of the RET proto-oncogene. The aim of this study was to evaluate the aggressiveness of medullary thyroid carcinoma (MTC) in patients with a proven germline mutation in codon 634 RET proto-oncogene, the occurrence of other associated diseases and survival analysis.Methods: The retrospectiv...

Aim: Functional neuroendocrine tumors (NETs) represent a specific diagnostic and therapeutic challenge, since hormonal clinical syndrome can severely complicate clinical picture and affect treatment. Our aim was to analyze characteristics and survival of functional pancreatic NETs.Materials and methods: We retrospectively analyzed data from 272 patients with pancreatic NETs treated at our department from the year 2005 till 2023. The patients underwent st...

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-age women. This highly complex reproductive metabolic disorder is independently associated with high prevalence of non-alcoholic fatty liver disease (NAFLD). While the gold standard of NAFLD diagnosis is liver biopsy or MRI, it is costly and hard to perform in large population. Recently, simple and convenient markers, such as liver fat score (LFS), fatty liver inde...

Introduction: Polycystic Ovary Syndrome (PCOS) stands out as the most prevalent endocrine disorder affecting women during their reproductive years. Diagnosis typically relies on the ESHRE/ASRM criteria, necessitating the presence of at least two of three criteria: anovulatory dysfunction (ANOV), hyperandrogenism (HA), and morphologically polycystic ovaries visualized through ultrasound (PCOM). Using these criteria, patients can be classified into four phenotypes: PCOS-A (HA+AN...

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases among women of reproductive age and is associated with many metabolic manifestations, such as obesity, insulin resistance, dyslipidaemia and hyperandrogenism. The aim of the research was to analyse lipid profile in women with PCOS and their phenotypes.Subjects and methods: We evaluated 159 women with PCOS diagnosed using ESHRE/ASRM criteria (PCOS: age: 25.85±5....

Introduction: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a dimeric enzyme that catalyzes the reduction of cortisone to cortisol within the endoplasmic reticulum. Loss of this activity results in a disorder termed cortisone reductase deficiency type 1 (CRD). Only mutations in H6PD gene, which encodes an enzyme supplying cofactor for the reaction, have been identified as the cause of disease. Biochemical features of CRD are increased cortisol clearance and A...